PAIA Biotech GmbH offers rapid analytics of various biologics (mainly Fc based proteins like IgG) via its proprietary assay technology. Our common customers work in discovery (antibody engineering), cell line development (CLD), upstream processing (USP) and analytical development (AD).

Below you can find the current assays in service.

DEVELOPABILITY:
- Polyreactivity: Ovalbumin binding, or Heparin binding, or chemically defined baculovirus particle binding (BVP)
- Hydrophobicity: Binding on HIC beads
- Surface charge: Binding on CEX beads

Purity:
Purity/Mispairing Assay: CEX based gradient assay which shows a charge profile
Purity/Mispairing Assay: HIC based gradient assay which shows a hydrophobicity profile

Glycans:
Glycan assays for various glycan types (N-linked and O-linked).

Our service features the following benefits:
- No more purification! We can handle any stage of impurity.
- No more quantification! We can quantify your samples and accept anything in µg/mL range and above.
- No more waiting! Results within 1~2 weeks depending on sample size.

We are able to offer this screening service for customers with time constraints and expanding pipelines.. Thanks to our high-throughput technology we can provide this service at a market-leading price per sample!

Requirement:
Glycan assays: Only 40-100 µg of non-purified sample protein depending on project scope.
Purity/mispairing assays (either CEX or HIC based): Only ~20 µg of non-purified sample protein.
Developability assays: Only 5~10 µg of non-purified sample protein.