Otava Research and Development Company Ltd, cooperating with leading Ukrainian research institutions, carries out research work in the format of outsourcing. The research team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for customers from all over the world. We offer research solutions in fields of medicinal chemistry and molecular biology. Whether you need to outsource a specific project, OtavaRD can provide you with quality and timely technical services.

Molecular Modeling and Bioinformatics Services:
• Gene and protein sequence analysis and alignment;
• Homology modeling;
• In silico protein modification analysis;
• In silico ADME predictions;
• In silico lead prediction;
• In silico lead optimization;
• In silico lead development;
• Binding site identification and analysis;
• Virtual screening;
• Pharmacophore modeling;
• Structure-activity relationship (SAR) analysis;
• Computational studies of drug-receptor interactions;
• Hit identification and optimization;
• Protein variability analysis;
• Protein secondary structure prediction;
• Protein disorder region prediction;
• Protein fold recognition;
• Protein structure analysis;
• Protein spatial structure quality evaluation;
• Protein spatial structure correction;
• Protein domain prediction;
• Ab initio protein spatial structure prediction;
• Protein molecular dynamics simulation;
• Nucleic acid molecular dynamic simulation;
• Molecular dynamic simulation of extra large heterogeneous systems;
• Accurate binding energy prediction;
• Analysis of differential gene expression (DGE);
• Next generation sequencing analysis;
• Gene expression clustering;
• Kohonen’s maps;
• Microarray data analysis;
• DNA spatial structure prediction;
• RNA spatial structure prediction;
• Aptamer structure prediction;
• Biomolecular contact surfaces prediction;
• Systems network analysis.

Chemical Services:
• Collection of screening compounds (200,000+ compounds) and chemical building blocks (3,000+ compounds);
• Synthesis of chemical building blocks;
• Synthesis of combinatorial libraries based on chemical scaffold;
• Custom synthesis of the biologically active compounds (inhibitors/activators, agonists/antagonists etc) on a stand-alone basis or as part of an integrated full service solution;
• Synthesis route development and improvement;
• Development of new multi-step synthesis pathways for the production of the complex molecules;
• Hit-to-lead & lead optimization;
• Cheminformatics, molecular modeling, virtual screening and QSAR in order to select/design compounds or target-focused libraries for various HTS screening and drug discovery projects.

Molecular Biology Services:
• Custom protein expression services;
• Proteins affinity chromatography;
• Transfection studies;
• Lentivirus-mediated stable transfection;
• Generation of stable cell lines;
• Immunoblotting;
• Immunostaining;
• Immunoprecipitation;
• qPCR;
• Cytotoxicity screening;
• Drugs testing assays;
• Custom anti-sense oligos design;
• Custom primers design.