Orphagen is an industry leader in orphan nuclear receptor translational research. We have developed and validated transcriptional and biochemical assays for a panel of nuclear receptors. We provide flexible nuclear receptor profiling and screening services. Compounds can be screened against single or multiple receptors in single or multiple doses for selectivity profiling and/or IC50 determination. Library screening service is available upon request. We are experienced in drug discovery and we meet the highest industry standards.

We perform validated assays for the following receptors:

• Metabolic receptors (FXR, LXRα,β; PPARα,δ,γ; and ERR α,β,γ)
• The steroid hormone receptors (ER, AR, PR and GR)
• Retinoid receptors (RARα,β,γ and RXRα)
• Orphan targets (RORα,β and LRH-1)
• Custom receptor assay development upon request