Organix., a Massachusetts, USA based corporation, (www.organixinc.com) established in 1986, is an internationally recognized provider of Contract Research in Synthetic Organic and Medicinal Chemistry. Organix owns and operates a state-of-the-art facility in Woburn, MA staffed by Ph.D. level scientists who conduct chemistry of any complexity. We provide Custom Synthesis of Molecules in all Structural Classes, Design and Synthesis of New Chemical Entities, Structure Activity Relationship Studies, Hit-to-Lead Studies, Development and Optimization of Synthetic Procedures and Design and Synthesis of Drug Conjugates in which active NCEs are tethered to HRP, PEG, HPMA-polymers, HPMA-copolymers, or other large molecules. These tethered NCEs can also be designed to cleave and release an NCE in situ.