We are a Laboratory Based CRO for Expression Proteomics, Chemical Proteomics -which are currently available, and In Vivo Services (coming very soon!).

⭐︎ Brief Overview of our Proteomics Services, and Laboratories & Equipments:

➢ PISA: Proteome Integral Solubility Alteration Assay for High Throughput Drug Target Finding (now also miniaturised for primary and iPSC derived cell cultures): Five (5) drugs can now be scanned at the same time in parallel with 3 Biological replicates, removing all inter-assay variability! High specificity, deep profiling and at an affordable price!

➢ Protein expression profiling: To deduce the mechanism of action of your drug candidate.

➢ ProTargetMiner: signature library of anticancer molecules, can be combined with other chemical proteomics methods.

➢ RedOx Proteomics: precisely quantify oxidative stress as a signature of disease progression or drug effect.

➢ Protein Structural Analysis using Hydrogen- Deuterium Exchange Mass Spectrometry (HDX-MS), e.g., epitope mapping etc.

➢ Large scale quantitative proteomics experiments using label-free or isobaric labelling (TMT and TMTpro) quantification strategies.

➢ Targeted proteome analysis, including SureQuant analysis of plasma/serum samples.

➢ Detection of post-translational modification and their localization on the amino acid sequence.

➢ General protein identification in gel and solution.

➢ Accurate molecular mass determination of peptides and small proteins.

Fully equipped and serviced laboratories:
✓ Cell culture and sample preparation laboratories.
✓ LC-MS Lab with advanced equipments: Nine (9) nLC-MS high resolution Orbitrap instruments (2x Fusion Lumos; 2x Exploris 480, Fusion; 2x Q-Exactive HF, Q-Exactive, 1x Eclipse).
✓ 2 separate UPLC systems for off-line peptide fractionation.
✓ Automated HDX-MS: CTC PAL Liquid Handling System on-line with LC-MS.
✓ Data analysis laboratory and workstations.