We are a Laboratory Based CRO for Proteomics and Chemical Proteomics.

🔶 Brief Overview of our Proteomics Services, and Laboratories & Equipments:

✅ HDX-MS analysis which is the best method for information on your protein structure, interaction sites, epitope mapping, conformational changes due to post-translational modifications etc.

✅ Post-translational Modifications (PTMs) detection and their localization on the amino acid sequence.

✅ PISA for Drug Target Identification/Deconvolution: Using our advanced & high-throughput chemical proteomics method: Five (5) drugs can now be scanned at the same time in parallel with 3 Biological replicates, removing all inter-assay variability! High specificity, deep profiling and at a very affordable price! (now also miniaturized for primary and iPSC derived cell cultures).

✅ PISA Express for Protein Expression Profiling: To deduce the mechanism of action of your drug candidate (upto 18 samples in one assay!). This can be also combined with drug target identification (PISA), which will save your time and money!

✅ SIESTA-PISA: The best high-throughput method to identify the potential substrate(s) of your enzyme.

✅ RedOx Proteomics: precisely quantify oxidative stress on the entire proteome (>9000 proteins), as a signature of disease progression or drug effect.

✅ Large scale Quantitative Proteomics experiments using label-free or isobaric labelling (TMT and TMTpro) quantification strategies.

✅ Targeted Proteome Analysis, including SureQuant analysis of plasma/serum samples.

✅ General protein identification in gel and solution. De Novo Sequencing.

✅ Accurate molecular mass determination of peptides and small proteins.

✅ ProTargetMiner: our signature library of anticancer molecules, which can be combined with other chemical proteomics methods to find the similarity of drug action with other existing drugs in cancer treatment.

✅ There are also many more tailored services and can share with you knowing your specific needs!

🔶 Fully equipped and serviced laboratories (Also Check Photos in the Media):

✅ Cell culture lab Instruments: Two laminar flow cabinets, Three CO2 incubators, Two Microscopes, Eppendorf centrifuge, BioRad cell counter, etc.

✅ Centrifuges: Beckmann XPN-80 ultracentrifuge, Speedvac centrifuges , Eppendorf centrifuges for large and small tubes

✅ Mass Spectrometers:
Two Orbitrap Fusion Lumos, Thermo Scientific
Two Orbitrap Q Exactives HF-X, Thermo Scientific
One Orbitrap Fusion, Thermo Scientific
Two Orbitrap Q Exactives HF, Thermo Scientific
One Orbitrap Q Exactive, Thermo Scientific

✅ Automated HDX-MS: LEAP PAL HDX Automation Liquid Handling System on-line with LC-MS.

✅ UPLC:
Two Ultimate 3000 RSLCnano for double column operation
Five UltiMate 3000 RSLCnano / nEasy-LC 1000 for nLC-MS
Ultimate 3000 for off-line high pH fractionation
Three UltiMate 3000 Nano LC or nEasy-LC 1000 for nLC-MS

✅ Data Analysis Hardware and Software:
Four PC stations, Proteome Discoverer 2.4, BioPharma Finder, Peaks, MaxQuant, Mascot, SIMCA, GraphPad PRISM, Excel, R, etc.