Since 2007, NIS has been a trail-blazing CRO providing cryo-EM services. Diverse skill sets and state-of-the art technology, including more transmission electron microscopes than any provider in North America, help NIS make cryo-EM imaging and analysis accessible to companies of all sizes, and to teams across the drug discovery pipeline.

As Thermo Fisher Scientific’s recommended provider of cryo-EM in North America, we help our clients accelerate the development of new and life changing therapeutics.

Service Areas:

Structural Biology using high resolution single particle analysis for structure-based drug design. We have solved over 150 3D structures of biological molecules to a resolution of 3.5 Å or better.
Examples: Protein (soluble and membrane), protein-ligand complexes, antigen-antibody complexes, PROTACs, and more

Nanoparticle characterization, which includes complete morphology assessment to inform size, shape, uniformity, purity, and cargo description, with quantitative analysis. Capabilities include both R&D and GMP services.
Examples: VLPs & viruses, AAV, LNPs & liposomes, EVs, Iron NPs, and more

For all services, we offer rapid turn-around times for all deliverables, all-digital data and remote access via a secure web-based portal.