Custom Synthesis – mg-kg scale

The specialized team at Mithros has a broad array of experience in preparing small molecule NCEs with high quality specifications. It is proficient in utilizing diverse methodologies to synthesise single, multi-step, small arrays as well as focused libraries. Our scientific team is also experienced in parallel synthesis of focused libraries for use in hit-to-lead and lead optimization projects.
Mithros possess a robust infrastructure including Parr reactor (25L; 100psi pressure), parallel synthesizers, rota-vapors etc. to execute projects for it partners. Our scientists also have access to relevant scientific literature and databases to ably troubleshoot their projects for on-time delivery of compounds. All our compounds are delivered with the requisite analytical reports including, but not limited to NMR, mass, HPLC etc.
At Mithros, we have delivered compounds used in medicinal, combinatorial, discovery chemistry, building blocks, scaffolds and libraries as well as various impurities and metabolites. Some of the chemistries routinely undertaken at Mithros include

Scale-up
Mithros helps scale-up compounds from mg to kilo and tonne scale via robust process development protocols. We have undertaken various chemistries for scale-up and after process development, have provided our partners with multi-kilo compounds.
We have access to broad infrastructure both in-house and via partner labs. Some of the infrastructure includes:
Glass and Stainless steel reactors (capacity from 10l-1000l)
Mulch filters/centrifuges
High vacuum pumps/driers
Heating (up to 200⁰C); cooling (u pto -70⁰C)
Mithros has also delivered several technology transfer projects in close collaboration with its German partner, Taros Chemicals GmbH & Co.KG.
For our clients, this collaboration offers the best of both worlds – seamless one-point contact in Europe and cost-effectiveness.