ITR Laboratories Canada Inc. is an accredited GLP-compliant pre-clinical CRO located in Montreal, Quebec (CANADA) established in 1989 – a center of excellence in toxicological evaluations of NCEs (small & large molecules), biosimilars, biomarkers and immunotherapy platforms in rodents, large animals and NHPs in support of IND/NDA/BLA regulatory submissions. From inception of IDEA to imminent EXIT strategy, ITR can facilitate reduction of your preclinical research outsourcing burn rates by offering custom cost effective, regulatory navigation and accelerated milestone driven strategies for your current and potential non-clinical drug development endeavors.

Mid-size facility (185,000 sq ft) with 72 animal rooms. Key services include:

- General toxicology (oral, IV, subcutaneous, intramuscular, intraperitoneal, …)
- Inhalation toxicology (liquid, powder, gas, suspension)
- Infusion toxicology (surgically implanted catheters, disposable indwelling catheters, implanted vascular access ports)
- Ocular toxicology (topical instillation, intraocular injections, ocular implants)
- Dermal toxicology (topical occluded or non-occluded, intradermal administration)
- Juvenile toxicology (rats)
- Safety Pharmacology (core battery: CV, FOB/Irwin, respiratory)
- Genetic toxicology
- Immunology (bioanaylysis by ELISA or ECLIA, biomarkers, dose formulation analysis, biodistribution, ADA, neutralizing Ab assays, immunotoxicology, mulitplex platform, flow cytometry, molecular biology…)
- Analytical and Bioanalytical services for small molecules (HPLC, LCMSMS)
- Pharmacy, clinical pathology, histology and pathology on site

- Also facilities in Japan for reproductive toxicology and in vitro models

Study types: PK, acute, sub-chronic, chronic, carcinogenicity (6-month and 2-year design)