in-ADME Research was founded in 2011, and has been responsible for providing unique software products and expert consulting services. Our specialty is in PHYSICOCHEMICAL PROFILING (solubility, dissolution, permeability, pKa/pH) applied to discovery and early development of drugs in pharmaceutical R&D. Our customers & clients value our expertise, something we have been collectively nourishing for nearly forty years.
The critical knowledge base for in-ADME Research has been summarized in the book written by one of the principals: Absorption and Drug Development Second Edition, Wiley, 2012. It serves as a unique resource and explores in depth the relationships between the ionization constant, solubility, and permeability as a function of pH, and applies this to the prediction of drug absorption and distribution into the brain.