George Mason University’s Biomedical Research Laboratory (BRL) constructed with the support and involvement of the National Institutes of Health, plays a critical role in advancing research related to infectious diseases. The BRL supports research programs in the National Center for Biodefense and Infectious Diseases focusing on host response using proteomics and nanotechnology as they are applied to diagnostic, therapeutic, and vaccine development. The BRL is equipped with state-of-the-art facilities to house multiple animal species, from rodents to nonhuman primates. A wide array of animal model developments are ongoing at the BRL with an emphasis on aerosol exposure. The agents of study include, but are not limited to, Francisella tularensis, Yersinia pestis, Bacillus anthracis, Burkholderia, Influenza virus, Rift Valley Fever virus, Dengue virus, and encephalitic alphaviruses (Venezuelan, Eastern, and Western equine encephalitis viruses).