The Center for Neural Informatics, Structures, and Plasticity (CN3) pursues fundamental breakthroughs in neuroscience by fostering neuroinformatic and computational approaches to neuroplasticity and neuroanatomy. By bringing together faculty expertise in these multiple disciplines, the Center provides opportunities for cross-training in neuroscience, psychology, and engineering, both at the graduate and postdoctoral levels. CN3 researchers investigate the relationship between brain structure, activity, and function from the subcellular to the network level, with a specific focus on the biophysical and biochemical mechanisms of learning and memory. In the long term, we seek to create large-scale, biologically plausible network models of entire portions of the mammalian brain, such as the hippocampus, to understand the neural circuits and cellular events underlying the expression, storage, and retrieval of associative memory.