Welcome to the Genomics Core of Cleveland Clinic’s Lerner Research Institute (LRI)! Our mission is to provide easy access to state-of-the-art DNA and RNA services to Cleveland Clinic’s investigators and to both external academic and commercial users.
The Genomics Core uses cutting-edge genomics technology to generate top-quality data with a rapid turn-around time and an affordable cost. We offer a wide range of services, including capillary sequencing and genotyping, Illumina microarray-based gene expression profiling and genotyping, and next-generation sequencing (NGS). Our lab is equipped with the renowned Illumina MiSeq desktop sequencer and the Illumina HiSeq2500, which enable rapid and effective targeted and whole genome analyses. We prepare and normalize libraries for RNA-seq, miRNA-seq, DNA-Seq, ChIP-seq, targeted exome sequencing, amplicon sequencing, bacterial 16S metagenomics and whole genome sequencing. Other services include DNA/RNA QC on an Agilent Technologies Bioanalyzer, shearing of DNA and chromatin with Covaris technology, and microarray data analysis support. We also collaborate with the Genomic Medicine Biorepository to extract DNA and RNA for our users.