The Biosample Repository Facility (BRF) coordinates the ethical collection, storage, annotation and distribution of human biosamples and associated comprehensive patient and family cancer history data, clinical interventions and lifestyle factors under an Institutional Review Board-approved protocol. We adhere to the International Society for Biological and Environmental Repositories and National Cancer Institute Best Practices for Biospecimen Resources and participate in the NCI Office of Biorepositories and Biospecimen Resources and Biospecimen Research Network. BRF expediates bidirectional flow from lab bench to clinic, and stimulates translational research associated with clinical trials and basic research. We provide tissue-based research services—including tissue microarray construction and immunohistochemistry, automated tissue image analysis and electrochemiluminescent enzyme-linked immunosorbent assay-based biomarker analysis—to support translational and basic research.