The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the library of small molecules for biologically active compounds in a variety of readout systems.
design & adjustment of readout systems;
set-up and optimization of screening conditions and protocols;
screening of diversified libraries of chemicals;
data processing;
assistance in designing program for chemically optimized lead compounds
The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the library of small molecules for biologically active compounds in a variety of readout systems. The MSC can provide help with the adjustment of readout systems for both cell-based and biochemical assays and establishment of screening conditions based on a pilot small-scale screening. If successful, the established system is used for a full-scale library screening in 96 well format followed by generation of the database with the results.
High throughput technology is not limited to drug discovery but can be used by any researcher to quickly conduct hundreds of thousands of biochemical, genetic or pharmacological tests.
The Core is open for researchers at CCF and other biomedical research centers in the Cleveland area.
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