The High Throughput Screening (HTS) Core assists City of Hope researchers in the identification of novel lead compounds for the development of anticancer drugs and of chemical probes useful for biochemical mechanistic studies. These objectives are achieved via sophisticated, high throughput screening assays of synthetic compound and natural product libraries.

A team of medicinal chemists, pharmacologists, structural biologists, bioinformaticians, and clinicians contributes valuable input and expertly optimizes some of these small molecules for the development of life-saving, cancer-fighting drugs. The team then translates these molecules and drugs into clinical evaluation in cancer patients.