A primary goal of City of Hope’s Comprehensive Cancer Center (CCC), and of its research programs, is to develop new, more effective, and less toxic therapies for the treatment of cancer. Thanks to extraordinary resources and brilliant minds, that goal is today more achievable than ever.

The Drug Discovery and Structural Biology (DDSB) Core was established to both technically and scientifically facilitate drug discovery efforts consistent with the translational research goals of the CCC. Two important points of focus for the DDSB, then, are chemical biology probes and discovery of cancer drugs in the area of molecular-targeted therapeutics.

Because the DDBS Core was established with these complex goals in mind, its services are impressively diverse but also highly convergent. The Core is comprised of four major service components: high throughput screening, biopolymer synthesis, small molecule synthesis and X-ray crystallography. These disciplines work together in a complementary and cohesive manner to provide a full array of early-phase drug discovery services and chemical probes for biological systems.