The Vector Core facility is available for use by Institutional Biosafety Committee (IBC) -approved investigators. The Vector Core team is able to provide intellectual and technical support. Please note, all cell lines must be certified as mycoplasma negative prior to use in the facility.

The Vector Core provides assistance in the design and construction viral vectors, as well as in the production of viral particles for gene-modified in vitro as well as in vivo studies. We currently can help design or produce vectors for experiments involving retrovirus, lentivirus, HSV-1, and AAV. We have numerous viral vectors that can be used by the Children’s Hospital Los Angeles and USC communities. The Vector Core also provides consulting services to help researchers identify their gene transfer needs, determine the best way to produce gene-modified cells, and to assist in experimental troubleshooting. To this end, members of the Vector Core provide a broad range of core competencies that will benefit our hospital researchers.