Calixar develops new approaches to isolate in solution – with the highest purity levels – full-length membrane antigens and proteins (GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins), while keeping their structural and functional integrity. Calixar’s approach represents an opportunity for pharmaceutical companies to start and work with high quality targets or antigens before formulating vaccines, developing antibodies, and/or discovering a primary lead through Structure Based Drug Design or High Throughput Screening assays.
CALIXAR’s team is trained to perform ligand binding assays using the MicroScale Thermophoresis (MST) combined with Isothermal Spectral Shift detection. This cutting-edge technology offers to scientists and researchers the possibility to obtain accurate ligand binding parameters and compare several ligands in terms of binding properties. Thanks to the Monolith X (Nanotemper) device, CALIXAR enhances its analytical capabilities for characterizing protein-ligand interactions adapted to a wide range of membrane targets (GPCRs, ion channels, transporters, enzymes, …).