ATEM Structural Discovery, a leading Contract Research Organization (CRO), specializes in analytical and structural cryo-electron microscopy (cryo-EM). Our state-of-the-art, fully commercial cryo-EM laboratory is equipped with an integrated wet lab, a Talos L120 room temperature microscope (ThermoFisher), and a Glacios cryo-EM system featuring an advanced direct electron detector camera (ThermoFisher). Additionally, we have an on-premises high-performance computational cluster.

Our primary strength lies in our highly integrated process, encompassing everything from sample preparation to result analysis, all within a single facility. We are at the forefront of developing proprietary Artificial Intelligence (AI) software for industrial applications in this field.

As a Good Manufacturing Practice (GMP) certified laboratory, we adhere to the highest standards of quality. Our services include:

- Cell Line Characterization and Bulk Harvest Analysis: GMP-compliant analysis for viral contamination studies.

- Lipid-Nano-Particle (LNP) Characterization: Utilizing the first AI-based solution for transforming images into fully quantitative data, aiding in formulation, stability studies, and batch-to-batch controls.

- Adeno-Associated Viral Vector (AAV) Characterization: Providing high-precision results from single-particle cryo-EM imaging for comprehensive characterization, including full, empty, and intermediate states.

- 3D Structure Epitope and Paratope Mapping: Streamlined cryo-EM process enabling detailed insights for antibody and biologics discovery, aiding in lead candidate selection or optimization.

- 3D Structure Mode of Action Study: Specialized in small molecules, offering extensive capabilities to enhance key quality attributes relevant to cryo-EM structure determination.

Our visualization capabilities extend across various modalities, including cells, nanoparticles, viruses and virus-like particles, and proteins.

By leveraging our expertise and cutting-edge technology, ATEM Structural Discovery is committed to advancing scientific understanding and supporting the development of novel solutions in the field of structural biology.