The main service that Resolian provides:

Biopharmaceutical Services (Bioanalytical for Large Molecule/Biologics)

• Method development, validation and sample analysis for large molecules
• PK/TK immunoassays (ELISA, ECL, MSD)
• Immunogenicity assays (ADA) (anti-drug antibody screening, confirmation, titer assessment, and neutralizing antibody (nAb) determination)
• Cell based bioassays (cytotoxicity, genotoxicity, reporter gene assay, and immunochemistry)
• Single and multiplex biomarker panels for RNAi, genotyping, gene expression, mutation, and methylation

GLP/Non-GLP Bioanalytical Support

• LC-MS/MS method development, validation and quantitative analysis of drug and metabolites in biological matrices
• LC-MS/MS method development, validation and quantitative analysis of proteins and peptides in biological matrices
• LC-MS/MS protein characterization
• Evaluation of PK/TK/PD
• In vivo PK/TK/PD screening
• In vitro screening
• Pesticide residue analysis, ILV

In Vitro Drug Metabolism and Drug Transporter Studies

• Metabolic stability (Intrinsic clearance) in various systems
• Direct and mechanism-based CYP inhibition
• CYP induction
• Reaction phenotyping
• Drug-drug interactions between small molecules and biologics
• MDCK/MDCK-MDR1/Caco-2 cell permeability
• Drug transporter assays for substrates and inhibitors
• Protein binding in plasma/whole blood/tissues
• Metabolite profiling, isolation, purification and identification
• Predictive routes of metabolism and potential toxicity
• In vitro species comparisons for appropriate pre-clinical animal model selection

• AAALAC accredited rodent vivarium for discovery PK studies