Overview

The advent of next-generation sequencing technologies has revolutionized molecular epi/genomics. While sequencing itself can now be provided as a fairly simple service, sequencing of genomes and epigenomes of very small numbers of cells, especially single cells, is not broadly available and requires specific expertise. These analyses require amplification and sequencing procedures that are not standard and quite difficult for individual laboratories to perform. In addition, computational and systems analysis, even at the level of standard whole cell population sequencing, remains far from routine. The facility has the infrastructure to provide single-cell assays at the genomic, epigenomic and transcriptomic level to stem cell biologists at Einstein.