Agro-Bio (sub-subsidiary of the diagnostics in vitro company Stago) is one of the French pioneer in the development and production of CUSTOM ANTIBODIES since 1975. REACTIVITY, high QUALITY service at COMPETITIVE PRICING as well as building long term and confidence-based collaboration with our customers are our key engagements. Our mission is to support each client to implement the best strategy for each project.

Agro-Bio provides its expertise for public research teams, CRO’s, biotech and IVD companies as well as renowned Big-Pharma (ISO9001/ISO13485/CIR).

Agro-bio offers a wide range of fully customized services:

BIOANALYTICS
- ADA reference samples for your immunogenicity tests
- Anti-idiotypic and/or neutralizing antibodies for PK/PD and potency tests
- BIACORE : afffinity, receptor binding, cynomolgous vs human
- Antibody characterization: stability, affinity, epitope mapping, sequencing, aggregation

BIOPRODUCTION
- Selection and validation of generic assays (preclinical and clinical phase I and II)
• Performance study of the generic HCPs ELISA
• Determination of ELISA suitability and accuracy: dilutional linearity, specificity, spike recovery, LOD / LOQ
• Coverage assessment of the antibodies of the generic HCPs ELISA (Required by the reglementary authorities)
- Development of a process specific (required from phase III)
• Bulk production/purification of process-specific HCP polyclonal antibodies on rabbit, goat or chicken.
• Validation of HCP antibodies: coverage assessment by 2D-DIBE (fluorescent based) and purification by affinity on HCP antigen
• Development and validation of process-specific HCPs ELISA kits
• Manufacturing of HCP ready-to-use ELISA kits
- Mass spectrometry analysis can be implemented as an orthogonal method.

IN VITRO DIAGNOSTICS
- Large scale mAb production (from mg to 10g-scale)
- Large scale pAB production (goat, rabbit, guinea pig, chicken, mice & rat)
- mAb & pAb development
- BIACORE® analysis: affinity, antibody pairs, stability

DISCOVERY
- Immunogen design & generation
- Target validation and Proof-of-concept antibody-tools
- R&D antibodies: mAB & pAb multi-species
- Conjugation, Fragmentation, Sequencing