Advaita Bioinformatics develops comprehensive bioinformatics tools that bridge the gap between the ability to gather and interpret genomic variants, transcriptomics, proteomics data, and other OMICS data. Our advanced methods and platform provide researchers with the most advanced and secure tools to understand underlying phenomena at a systems biology level while minimizing false positives. Advaita’s HIPAA compliant applications allow users to quickly and intuitively understand expression and variant data and combine various ‘omics data to quickly gain deep biological understanding.

Advaita’s services span the entire workflow from basic processing of FastQ files to deep interpretation of integrated omics data for subtyping and feature identification. Our scientific staff have a combined 200+ publication with over 10,000 citations. While not exhaustive, here are some of the most common services we provide:

• Group Comparisons: one- and two-way ANOVA, t-test, Chi-square test, Categorical Data analysis methods
• Unsupervised Learning/ Multivariate Methods: PCA, Hierarchical and k-means Clustering, Gaussian Mixture Models (EM), PINS (proprietary methodology)
• Statistical Modeling and Classification: Neural Nets, Support Vector Machines, Decision Trees, Random Forests, Logistic/ LASSO Regression, Linear Regression
• Genotype Associations: GWAS
• Systems Biology: Topological Algorithms for Ranking Biomolecular Pathways,Gene Ontology Pruning Methods, Agent-Based Modeling, Parameter Sensitivity/Uncertainty Analysis
• Functional Interpretation & Analysis: Predicted miRNA Analysis, Gene Ontology Analysis with advanced pruning, Pathway Analysis using “Impact Analysis”, Disease Analysis, Meta-Analysis, Variant Annotation & Prioritization
• Omics Data Types: Transcriptomics (microarray, RNASeq, NanoString nCounter), Genomics (WGS, WES, SNP arrays), Proteomics (Mass Spec, Multiplexed Cytokines), Metabolomics
• Programming Languages/ Platforms: R, Bioconductor, Python, SQL, Perl, Unix, Java
• Clinical/ Biological Domains: Type II Diabetes, Acute Respiratory Distress Syndrome, Pediatric Acute Liver Failure, Trauma/ Hemorrhagic Shock (serum and hepatocytes), Sepsis/ MODS, Ischemia/ Reperfusion, Wound Healing, Tuberculosis, Pre-Eclampsia, Alzheimer’s Disease, Cancer