Human FKBP12 / FKBP1A Protein, His Tag

DESCRIPTION

Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

DETAILS

Tag: C-6×His
Host: E. coli
Size: 100ug
Buffer: 50 mM HEPES, 150 mM NaCl, pH7.5
Format: Powder
Purity: 95%
Source: Human FKBP12, His Tag (FKA-H5122) is expressed from E. coli cells. It contains AA Met 1 - Glu 108 (Accession # P62942-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: FKBP12
Accession: NP_000792.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Met 1 - Glu 108
Swiss-prot: P62942-1
Package Size: 100ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 12.8 kDa
Shipping Condition: RT
Species Reactivity: Human
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