KLF4 Blocking Peptide (C-term)

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 9314
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: KLF4
Other Names: Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4, EZF, GKLF
Availability: 2 weeks
Bio Background: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Bio References: Yet S.-F.,et al.J. Biol. Chem. 273:1026-1031(1998). Foster K.W.,et al.Cell Growth Differ. 10:423-434(1999). Camacho-Vanegas O.,et al.FASEB J. 27:432-436(2013). Garrett-Sinha L.A.,et al.Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45(2004).
Primary Accession: O43474
Targetspecificity: The synthetic peptide sequence is selected from aa 408-420 of HUMAN KLF4