CCND1 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 595
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: CCND1
Availability: 2 weeks
Bio Background: CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Bio References: He,Y.Y., Cancer Res. 68 (10), 3752-3758 (2008)Marsit,C.J., Clin. Cancer Res. 14 (8), 2371-2377 (2008)Caldon,C.E., Cancer Res. 68 (8), 3026-3036 (2008)
Primary Accession: Q6FI00
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2612a was selected from the N-term region of human CCND1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.