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17699

MM-102

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C35H49F2N7O4/c1-5-34(6-2,43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24/h11-18,22,27-28H,5-10,19-21H2,1-4H3,(H,41,47)(H,42,48)(H,43,45)(H,44,46)(H4,38,39,4
  • Purity: ≥98%
  • Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation
  • Smiles: NC(NCCC[C@@H](C(NC1(CCCC1)C(NC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)=O)=O)NC(C(CC)(CC)NC(C(C)C)=O)=O)=N
  • Inchikey: RZKSQRIPRKWVBU-MHZLTWQESA-N
  • Cas Number: 1417329-24-8
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C35H49F2N7O4
  • Formula Weight: 669.8
  • Shelf Life Days: 1460

DESCRIPTION

A WDR5/MLL interaction inhibitor (IC50 = 2.4 nM) that blocks MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis; inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins