Biotinylated Human IGF-I R / CD221 Protein, His,Avitag™

DESCRIPTION

The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.

DETAILS

Tag: C-10×His & C-Avi
Host: HEK293
Size: 200ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 90%
Source: Biotinylated Human IGF-I R, His,Avitag (IGR-H82E3) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Asn 932 (Accession # P08069-1).
Storage: -20℃
Category: MABSol® Biotin Labeled Proteins
Molecule: IGF-I R
Accession: NP_000866.1
Conjugate: Biotin-labeled
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. After reconstitution, this product is stable after storage at -20°C or lower.
Exp Region: Glu 31 - Asn 932
Swiss-prot: P08069-1
Package Size: 200ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 106.6 kDa. The protein migrates as 40-55 kDa,60 kDa and 95-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 106.6 kDa
Shipping Condition: RT
Species Reactivity: Human
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