CBX8 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 57332
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: CBX8
Other Names: Chromobox protein homolog 8, Polycomb 3 homolog, Pc3, hPc3, Rectachrome 1, CBX8, PC3, RC1
Availability: 2 weeks
Bio Background: Chromobox homolog 8 (CBX8 or Pc3) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression of PcG proteins have been associated with cancer. CBX8 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain, which is 40 to 50 amino acids long.
Bio References: Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000).
Primary Accession: Q9HC52
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2515a was selected from the N-term region of human CBX8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.