HRI Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 27102
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: EIF2AK1
Other Names: Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-controlled repressor, HCR, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, Hemin-sensitive initiation factor 2-alpha kinase, EIF2AK1, HRI, KIAA1369
Availability: 2 weeks
Bio Background: The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme.
Bio References: Rafie-Kolpin, M., et al., Biochemistry 42(21):6536-6544 (2003).Chen, J.J., et al., Trends Biochem. Sci. 20(3):105-108 (1995).
Primary Accession: Q9BQI3
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP8065a was selected from the N-term region of human HRI . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.