Mouse Complement C5a Protein, His Tag

DESCRIPTION

Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.

DETAILS

Tag: N-10×His
Host: E. coli
Size: 1mg
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Mouse Complement C5a, His Tag (C5A-M51H4) is expressed from E. coli cells. It contains AA Asn 679 - Arg 755 (Accession # P06684).
Storage: -20℃
Category: Cytokines&Growth Factors
Molecule: Complement C5a
Accession: NP_034536.2
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Asn 679 - Arg 755
Swiss-prot: P06684
Package Size: 250ug*4
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 10.9 kDa. The protein migrates as 14 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 10.9 kDa
Shipping Condition: RT
Species Reactivity: Mouse
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