EGFR Antibody (Y1197) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 1956
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: EGFR
Other Names: Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1
Availability: 2 weeks
Bio Background: The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
Bio References: Zanardi, T.A., et al., J. Virol. 77(21):11685-11696 (2003).Krug, A.W., et al., J. Biol. Chem. 278(44):43060-43066 (2003).Huang, F., et al., J. Biol. Chem. 278(44):43411-43417 (2003).He, Y.Y., et al., J. Biol. Chem. 278(43):42457-42465 (2003).Hirsch, F.R., et al., J. Clin. Oncol. 21(20):3798-3807 (2003).
Primary Accession: P00533
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7628r was selected from the Y1197 region of human EGFR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.