- Purity: 0.98
- Category: Compounds
- Lead Time: 12-16 weeks
- Molecular Weight: 534.48
- Molecular Formula: C29H29Cl2N5O
AMG-548 dihydrochloride is a selective, orally active p38α inhibitor with a Ki value of 0.5 nM, a slight selectivity for p38β (Ki=36 nM) and >1000-fold selectivity for p38γ and p38δ. AMG-548 dihydrochloride exhibits inhibition of whole blood LPS-stimulated TNFα with an IC50 value of 3 nM. AMG-548 dihydrochloride directly inhibited casein kinase 1 isoforms δ and ε, and inhibited Wnt signaling.
Lead Time: < 1 weekSign in to view pricing