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AMG-548 dihydrochloride


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  • Purity: 0.98
  • Category: Compounds
  • Lead Time: 12-16 weeks
  • Molecular Weight: 534.48
  • Molecular Formula: C29H29Cl2N5O


AMG-548 dihydrochloride is a selective, orally active p38α inhibitor with a Ki value of 0.5 nM, a slight selectivity for p38β (Ki=36 nM) and >1000-fold selectivity for p38γ and p38δ. AMG-548 dihydrochloride exhibits inhibition of whole blood LPS-stimulated TNFα with an IC50 value of 3 nM. AMG-548 dihydrochloride directly inhibited casein kinase 1 isoforms δ and ε, and inhibited Wnt signaling.

Lead Time: < 1 week

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