PIASy1 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 51588
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PIAS4
Other Names: E3 SUMO-protein ligase PIAS4, 632-, PIASy, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma, PIAS-gamma, PIAS4, PIASG
Availability: 2 weeks
Bio Background: PIASy1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. PIASy1 is involved in gene silencing, and promotes PARK7 sumoylation.
Bio References: Imoto, S., et al., J. Biol. Chem. 278(36):34253-34258 (2003).Chun, T.H., et al., Circ. Res. 92(11):1201-1208 (2003).Subramanian, L., et al., J. Biol. Chem. 278(11):9134-9141 (2003).Liu, B., et al., Proc. Natl. Acad. Sci. U.S.A. 98(6):3203-3207 (2001).Liu, B., et al., Proc. Natl. Acad. Sci. U.S.A. 95(18):10626-10631 (1998).
Primary Accession: Q8N2W9
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP1250a was selected from the C-term region of human PIASy1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.