TCEB1 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 6921
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ELOC
Other Names: Transcription elongation factor B polypeptide 1, Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15, TCEB1
Availability: 2 weeks
Bio Background: This gene encodes the protein elongin C, which is asubunit of the transcription factor B (SIII) complex. The SIIIcomplex is composed of elongins A/A2, B and C. It activateselongation by RNA polymerase II by suppressing transient pausing ofthe polymerase at many sites within transcription units. Elongin Afunctions as the transcriptionally active component of the SIIIcomplex, whereas elongins B and C are regulatory subunits. ElonginA2 is specifically expressed in the testis, and capable of forminga stable complex with elongins B and C. The von Hippel-Lindau tumorsuppressor protein binds to elongins B and C, and thereby inhibitstranscription elongation.
Bio References: Marcsisin, S.R., et al. J. Mol. Biol. 402(5):892-904(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lievens, S., et al. J. Proteome Res. 8(2):877-886(2009)Jalava, S.E., et al. Int. J. Cancer 124(1):95-102(2009)Piessevaux, J., et al. J. Biol. Chem. 283(31):21334-21346(2008)
Primary Accession: Q15369