Tolbutamide

DESCRIPTION

A SUR1/Kir6.2 channel inhibitor (IC50 = 4.9 µM); selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively); increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets; reduces blood glucose levels in a mouse model of STZ-induced diabetes at 80 mg/kg

DETAILS

Inchi: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
Purity: ≥98%
Raptas: Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes
Smiles: CC1=CC=C(S(NC(NCCCC)=O)(=O)=O)C=C1
Inchikey: JLRGJRBPOGGCBT-UHFFFAOYSA-N
Cas Number: 64-77-7
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C12H18N2O3S
Formula Weight: 270.3
Shelf Life Days: 1460