Human Angiopoietin-like 3 / ANGPTL3 Protein, Fc Tag

DESCRIPTION

Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.

DETAILS

Tag: C-Fc
Host: HEK293
Size: 100ug
Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, 0.05% CHAPS, pH7.5
Format: Powder
Purity: 90%
Source: Human Angiopoietin-like 3 Protein, Fc Tag (AN3-H5253) is expressed from human 293 cells (HEK293). It contains AA Ser 17 - Glu 460 (Accession # Q9Y5C1-1).
Storage: -20℃
Category: Cytokines&Growth Factors
Molecule: Angiopoietin-like 3
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ser 17 - Glu 460
Swiss-prot: Q9Y5C1-1
Package Size: 100ug*1
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 78.2 kDa. The protein migrates as 65 kDa and 100-115 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 78.2 kDa
Shipping Condition: RT
Species Reactivity: Human
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