Phospho-Rb(S788) Antibody Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5925
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: RB1
Other Names: Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1
Availability: 2 weeks
Bio Background: RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
Bio References: Wagner, S., et al., Biochem. Pharmacol. 69(7):1059-1067 (2005).Roesch, A., et al., Mod. Pathol. 18(4):565-572 (2005).Lieman, J.H., et al., J. Biol. Chem. 280(11):10484-10490 (2005).Budde, A., et al., Oncogene 24(10):1802-1808 (2005).Zapata, E., et al., FEBS J. 272(6):1343-1353 (2005).
Primary Accession: P06400
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP3238a was selected from the region of human Phospho-Rb-S788. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.