37296
E6446 (hydrochloride)
Cayman Chemical
DESCRIPTION
A TLR7 and TLR9 antagonist (IC50s = 1.78 and 0.01 µM, respectively); selective for TLR7 and TLR9 over TLR4 (IC50 = 10.58 µM); inhibits CpG ODN2216- or RNA40-induced IL-6 production in isolated mouse BMDCs; prevents increases in left ventricle chamber size and cardiac fibrosis in a mouse model of transverse aortic constriction-induced heart failure at 1.5 mg/animal; increases survival and reduces increases in right ventricular systolic pressure and hypertrophy in a rat model of monocrotaline-induced pulmonary hypertension at 10 mg/kg; has been used to enhance the transfection efficiency of cell-penetrating peptides for the delivery of mRNA in vitro
DETAILS
- Inchi: InChI=1S/C27H35N3O3.2ClH/c1-2-14-29(13-1)17-5-19-31-23-9-7-22(8-10-23)27-28-25-12-11-24(21-26(25)33-27)32-20-6-18-30-15-3-4-16-30;;/h7-12,21H,1-6,13-20H2;2*1H
- Purity: ≥95%
- Raptas: Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition
- Smiles: C1(C2=CC=C(C=C2)OCCCN3CCCC3)=NC4=C(C=C(C=C4)OCCCN5CCCC5)O1.Cl.Cl
- Inchikey: DQOUZINBHKWGGM-UHFFFAOYSA-N
- Cas Number: 1345675-25-3
- Formulation: A solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C27H35N3O3 • 2HCl
- Formula Weight: 522.5
- Shelf Life Days: 1460