Phospho-p16-INK4A-S8 Antibody Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 1029
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: CDKN2A
Other Names: Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1
Availability: 2 weeks
Bio Background: p16-INK4A functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. This protein acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. The gene for this protein is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Bio References: Ausserlechner, M.J., et al., Leukemia 19(6):1051-1057 (2005).Kawamata, N., et al., Eur. J. Haematol. 74(5):424-429 (2005).Wang, J.L., et al., Mod. Pathol. 18(5):629-637 (2005).Kuroda, H., et al., Cancer Genet. Cytogenet. 158(2):172-179 (2005).Fu, G.H., et al., FEBS Lett. 579(10):2105-2110 (2005).
Primary Accession: P42771
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP3186a was selected from the region of human Phospho-p16-INK4A-S8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.