CDC25B Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 994
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: CDC25B
Other Names: M-phase inducer phosphatase 2, Dual specificity phosphatase Cdc25B, CDC25B, CDC25HU2
Availability: 2 weeks
Bio Background: CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined.
Bio References: Uchida, S., et al., Biochem. Biophys. Res. Commun. 316(1):226-232 (2004).Ito, Y., et al., Int. J. Mol. Med. 13(3):431-435 (2004).Wu, W., et al., Cancer Res. 63(19):6195-6199 (2003).Mils, V., et al., Exp. Cell Res. 285(1):99-106 (2003).Theis-Febvre, N., et al., Oncogene 22(2):220-232 (2003).
Primary Accession: P30305
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7256c was selected from the Center region of human CDC25B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.