mouse monoclonal IgG1; GS27 Antibody (F-6) is an IgG1 κ mouse monoclonal GS27 antibody (also designated GS27 antibody) that detects the GS27 protein of mouse, rat and human origin by WB, IP, IF and ELISA. GS27 Antibody (F-6) is available as both the non-conjugated anti-GS27 antibody form, as well as multiple conjugated forms of anti-GS27 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In eukaryotic cells, the Golgi apparatus receives newly synthesized proteins from the endoplasmic reticulum and delivers them after covalent modification to their destination in the cell. For membrane-directed proteins this process is believed to be carried out via vesicular transport. Correct vesicular transport is determined by specific pairing of vesicle-associated SNAREs (v-SNAREs) with those on the target membrane (t-SNAREs). This complex then recruits soluble NSF attachment proteins (SNAPs) and N-ethylmaleimide-sensitive factor (NSF) to form the highly stable SNAP receptor (SNARE) complex. The forma-tion of a SNARE complex pulls the vesicle and target membranes together and may provide the energy to drive the fusion of the lipid bilayers. GS27 and GS28 belong to the SNARE protein family and are important trafficking proteins between the endoplasmic reticulum and the Golgi and between Golgi subcompartments. GS27 and GS28 both exist as cytoplasmically oriented integral membrane proteins. The human GS27 gene, which maps to chromosome 17q21, is located near a locus implicated in familial essential hypertension, indicating that it is a potential candidate gene for this disease. The human GS28 gene maps to chromosome 17q11.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.