Human Tyk2 Protein, His Tag (active enzyme)

DESCRIPTION

Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.

DETAILS

Tag: N-10×His
Host: InsectCells
Size: 100ug
Buffer: 50 mM Tris, 150 mM NaCl, 1mM DTT, pH7.5
Format: Liquid
Source: Human Tyk2 Protein, His Tag (TY2-H5547) is expressed from Baculovirus-Insect cells. It contains AA Pro 871 - Cys 1187 (Accession # P29597-1).
Storage: -70℃
Category: Enzymes
Molecule: Tyk2
Conjugate: Unconjugated
Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Exp Region: Pro 871 - Cys 1187
Swiss-prot: P29597-1
Package Size: 100ug*1
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 38.5 kDa. The protein migrates as 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 38.5 kDa
Shipping Condition: Dry ice
Species Reactivity: Human
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