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TY2-H5547-100ug TY2-H5547-1mg

Human Tyk2 Protein, His Tag (active enzyme)

ACROBiosystems

DESCRIPTION

Human Tyk2 Protein, His Tag (TY2-H5547) is expressed from Baculovirus-Insect cells. It contains AA Pro 871 - Cys 1187 (Accession # P29597-1).

DETAILS

  • Tag: N-10×His
  • Host: InsectCells
  • Size: 1mg
  • Buffer: 50 mM Tris, 150 mM NaCl, 0.05% Brij-35, 1mM DTT, pH7.5
  • Format: Liquid
  • Storage: -70℃
  • Category: Enzymes
  • Molecule: Tyk2
  • Conjugate: Unconjugated
  • Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
  • Background: Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.
  • Exp Region: Pro 871 - Cys 1187
  • Swiss-prot: P29597-1
  • Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 38.5 kDa. The protein migrates as 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 38.5 kDa
  • Shipping Condition: Dry ice
  • Species Reactivity: Human
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html