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FCM-C82W3-25ug FCM-C82W3-200ug

Biotinylated Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)

ACROBiosystems

DETAILS

  • Tag: C-10×His & C-Avi | Native
  • Host: HEK293
  • Size: 25ug
  • Buffer: PBS, pH7.4
  • Format: Powder
  • Purity: 95%
  • Storage: -20℃
  • Category: MABSol® Biotin Labeled Proteins
  • Molecule: FcRn (FCGRT & B2M)
  • Accession: NP_001271480.1 (FCGRT) &
  • Conjugate: Biotin-labeled
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 12 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
  • Exp Region: Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M)
  • Swiss-prot: Q8SPV9-1 (FCGRT) & Q8SPW0-1 (B2M)
  • Characteristics: Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag, produced by co-expression of FCGRT and B2M, has a calculated MW of 34.1 kDa (FCGRT) and 11.6 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus , followed by an Avi tag (Avitag™) and subunit Beta-2 microglobulin (B2M) contains no tag at the C-terminus. The reducing (R) protein migrates as 35-40 kDa (FCGRT) and 13 kDa (B2M) respectively due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 34.1 kDa (FCGRT) & 11.6 kDa (B2M)
  • Shipping Condition: RT
  • Species Reactivity: Cynomolgus / Rhesus macaque
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html

DESCRIPTION

Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag, is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # Q8SPV9-1 (FCGRT) & Q8SPW0-1 (B2M)). In the region Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M), the AA sequence of Cynomolgus and Rhesus macaque FcRn (FCGRT&B2M) are homologus.