AKT1 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 207
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: AKT1
Other Names: RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1, PKB, RAC
Availability: 2 weeks
Bio Background: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Bio References: Liao, Y., et al., Int. J. Cancer 107(4):676-680 (2003).Powell, D.J., et al., Mol. Cell. Biol. 23(21):7794-7808 (2003).Debnath, J., et al., J. Cell Biol. 163(2):315-326 (2003).Li, G., et al., Oncogene 22(44):6891-6899 (2003).Liao, Y., et al., Mol. Cell. Biol. 23(19):6836-6848 (2003).
Primary Accession: P31749
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7028b was selected from the C-term region of human AKT1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.