Human Serpin D1 / Heparin Cofactor II Protein, His Tag

DESCRIPTION

Serpin D1 is also known as Heparin cofactor 2 (HCF2), Protease inhibitor leuserpin-2 (HLS2), Heparin cofactor II (HC-II), which belongs to the serpin family. HCF2 is expressed predominantly in liver. Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, SerpinD1 / HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). In a glycosaminoglycan-independent manner, serpinD1 / HC-II also inhibits chymotrypsin. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.

DETAILS

Tag: C-6×His
Host: HEK293
Size: 50ug
Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5
Format: Powder
Purity: 95%
Source: Human Serpin D1, His Tag (HC2-H5224) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Ser 499 (Accession # AAH35028).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: Serpin D1
Accession: AAH35028
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Gly 20 - Ser 499
Swiss-prot: P05546
Package Size: 50ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.7 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 55.7 kDa
Shipping Condition: RT
Species Reactivity: Human
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