Phospho-STAT3(S727) Antibody Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 6774
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: STAT3
Other Names: Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF
Availability: 2 weeks
Bio Background: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. Transcript Variant: This variant (1) represents a longer transcript, and encodes a longer isoform (1).
Bio References: Schick, N., et al., J. Biol. Chem. 279(37):38787-38796 (2004).Wang, H., et al., Lab. Invest. 84(8):941-951 (2004).Kato, T., et al., J. Biol. Chem. 279(30):31076-31080 (2004).Ivanova, A.V., et al., J. Mol. Biol. 340(4):641-653 (2004).Park, J., et al., Biochem. Biophys. Res. Commun. 320(1):279-285 (2004).
Primary Accession: P40763
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP3260a was selected from the 721-733 region of human Phospho-STAT3-Y727. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.