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OXL-M526x-100ug OXL-M526x-1mg

Mouse OX40 Ligand / TNFSF4 Protein, Fc Tag

ACROBiosystems

DESCRIPTION

Mouse OX40 Ligand, Fc Tag (OXL-M526x) is expressed from human 293 cells (HEK293). It contains AA Gln 49 - Leu 198 (Accession # P43488).

DETAILS

  • Tag: N-Fc
  • Host: HEK293
  • Size: 1mg
  • Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
  • Format: Powder
  • Purity: 95%
  • Storage: -20℃
  • Category: Immune Checkpoint Proteins
  • Molecule: OX40 Ligand
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
  • Exp Region: Gln 49 - Leu 198
  • Swiss-prot: P43488
  • Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 43.8 kDa. The protein migrates as 47-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 43.8 kDa
  • Shipping Condition: RT
  • Species Reactivity: Mouse
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html