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P0319

Polymyxin B sulfate, 100MU

Bio Basic

DETAILS

  • Cas: 1405-20-5
  • Grade: USP
  • Sap Code: A610319-0100
  • Unspsc Code: 51101500
  • Bbi Code Sku: P0319.SIZE.100MU
  • Unspsc Category: Antibiotics and Antimycotics
  • Storage Conditions: 2 to 8C
  • Tags Search Keywords: Antibiotics; Polymyxin B sulfate; Biobasic; Bio Basic; Bio Basics; Biobasics
  • Product Category Level 1: Antibiotics
  • Product Category Level 2: Powdered
  • Shipping Conditions Rtice: ICE
  • Refrigeration Requirements: Refrigerator

DESCRIPTION

Polymyxin B sulfate: Polymyxin B sulfate (PMB) is a strongly cationic cyclic polypeptide antibiotic isolated from fermentation of Bacillus polymyxa. PMB is a variable mixture of B1 and B2 (predominantly B1). Polymyxins combine with cell membranes and disrupt normal permeability to small molecules. Polymyxin B and the other polymyxin antibiotics act primarily by binding membrane phospholipids and disrupting the cytoplasmic membrane, inducing pore formation in bacterial walls (large enough to permit nucleotide leakage). Polymyxin B binds to the lipid-A portion of the lipopolysaccharide in the cell membrane of Gram-negative bacteria. The interaction involves ionic forces between amino groups in Polymyxin B and phosphate and carboxyl groups in the lipid A-Kdo region, with hydrophobic interactions between the respective acyl groups. Data suggest a stoichiometric binding of one LPS monomer to one polymyxin B molecule. “Polymyxin B has a bactericidal action on most Gram-negative bacilli (E. coli, e.g.) except proteus spp. ... not active against Neisseria species, ... most fungi and Gram-positive bacteria." Activity is inhibited by iron (II), Co (II), Mn (II) and magnesium ions. Polymyxin B may be incompatible with other microbial agents, including amphotericin, cephalothin sodium, cephasolin sodium, chloramphenicol sodium succinate and tetracycline hydrochloride; it is also incompatible with heparin sodium and prednisolone sodium phosphate