GSK778

DESCRIPTION:

GSK778 (iBET-BD1) is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 phenocopies the effects of pan-BET inhibitors in cancer models[1].

DETAILS

Purity: >98%
Smiles: CC1=NOC(C)=C1C2=C(OC[C@@H]3CNCC3)C=C4C5=C(N=C(COC)N5[C@H](C)C6=CC=CC=C6)C=NC4=C2
Category: Reference compound
Lead Time: 1-2 days
Cas Number: 2451862-42-1
Molecular Weight: 511.61
Molecular Formula: C30H33N5O3

Lead Time: < 1 week